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Sami Raheem Hasan
Department of Anesthesiology Technologies, College of Health and Medical Techniques, Sawa
University, Almuthana, Iraq.
Abstract
Background: Several benefits were imputed to ketamine such as its analgesic, amnesic effects,
maintenance of muscle tension, as well as protection for airway re-flexes and spontaneous
respiration.
Rationale: alteration in the hemodynamic status of the population under- went intravenous
induction of anesthesia is a common complication especially in propofol usage, where significant
reduction in blood pressure had been noticed, also assessment of ketamine on cardiac function
has not well described.
Aim: to evaluate the hemodynamic parameters (blood pressure (B.P) heart rate (H.R)) in
response to the propofol-ketamine mixture for adults and pediatric patients during different time
intervals.
Methodology: the patients were divided into two age groups; group A: twenty-five (25) Patients
who received propofol 2 mg/kg plus ketamine 0.3 mg/kg I.V, and group B: twenty five (25)
patients received propofol plus ketamine (using syringe mixture of 5 mg/ml propofol & 5 mg/ml
ketamine) I.V. on hemodynamic changes; heart rate (H.R) and blood pressure(B.P) which
monitored and recorded at different time intervals with respect of using other drugs like opioid
analgesia.
Result: H.R of the pediatric group was decreased un-markedly at induction and after 1min. and
5min, after induction. While the H.R of adult group was unchanged at induction but decreased after
1min. and 5min. after induction but unremarked, the means of different age groups heart rates
were higher among the pediatric age group, regarding the blood pressure means, whether systolic
or diastolic were unchanged at different occasions.
Conclusion: the propofol Ketamine is an effective safe inductive agent, low injectable pain
incidence, and a rapid onset of action, so producing preferable hemodynamic stability.
Keywords— propofol, Ketamine, adult, pediatric, hemodynamic parameters.
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